Expression of Growth Hormone Secretagogue-Receptors by Growth Hormone-Releasing Hormone Neurons in the Mediobasal Hypothalamus

Expression of growth hormone secretagogue receptor on growth hormone-releasing hormone neurons and neuropeptide Y neurons in the arcuate nucleus of rat hypothalamus.

Ghrelin is an endogenous ligand for growth hormone secretagogue (GHS) receptor (GHSR) in stomach extract. GHSs and ghrelin stimulate growth hormone (GH) secretion and food intake. In the hypothalamus, GHSR mRNA is expressed in GH-releasing hormone (GHRH) neurons and neuropeptide Y (NPY) neurons of the arcuate nucleus, which are involved in the regulatory mechanism of GH secretion and feeding be...

Growth hormone releasing hormone (GHRH) activates sleep regulatory neurons of the rat preoptic hypothalamus

We examined whether growth hormone releasing hormone GHRH may promote non-REM sleep via activation of GABAergic neurons in the preoptic area. Male Sprague-Dawley rats were implanted with EEG, EMG electrodes and a unilateral intracerebroventricular (icv) cannula. Groups of rats received icv injections (3 μl) with GHRH (0.1 nmol/100 g body wt) or equal volume of physiological saline at the onset ...

Growth hormone-releasing hormone activates sleep regulatory neurons of the rat preoptic hypothalamus.

We examined whether growth hormone-releasing hormone (GHRH) may promote non-rapid eye movement (NREM) sleep via activation of GABAergic neurons in the preoptic area. Male Sprague-Dawley rats were implanted with EEG, EMG electrodes and a unilateral intracerebroventricular cannula. Groups of rats received injections (3 microl icv) with gonadotropin-releasing hormone (GHRH) (0.1 nmol/100 g body wt...

Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat.

Synthetic GH secretagogues (GHSs) act via a receptor (GHS-R) distinct from that for GH-releasing hormone (GHRH). We have studied the hypothalamic expression and regulation of this receptor by in situ hybridization using a homologous riboprobe for rat GHS-R. GHS-R mRNA is prominently expressed in arcuate (ARC) and ventromedial nuclei (VMN) and in hippocampus, but not in the periventricular nucle...

Comparison of Expression of Growth Hormone-Releasing Hormone and Its Receptor Splice Variant 1 in Different Stages of Endometriosis